An Interventional Device to prevent Heart Failure-Karen Havenstrite & Ryan Krone-05/29/2012 - 8:30am

Event Information
Event Topic: 
An Interventional Device to prevent Heart Failure
Event Date: 
05/29/2012 - 8:30am
Event Location: 
Sunnyvale City Council Chambers, 456 West Olive Ave., Sunnyale, CA
Speaker Information
Event Speaker: 
Karen Havenstrite & Ryan Krone
Event Speaker Title: 
Chief Scientific Officer (KH) & Lead Mechanical Engineer (RK)
Event Speaker Company: 
COR Innovations
Event Speaker Bio: 

Karen Havenstrite

Ryan Krone

While studying for her B.S. in Chemical Engineering at Cornell University, Karen Havenstrite developed her passion for research, working on projects that included characterizing polymer melt rheology, developing technologies for biosensors, and designing wound dressings for burn victims. She then received her M.S. and Ph.D. in Chemical Engineering from Stanford University where her interdisciplinary work in the lab of Dr. Helen Blau combined polymer chemistry, biomaterials, and stem cell biology. She developed a hydrogel to mimic the rigidity of muscle tissue, and used this to provide the first transplantation studies demonstrating the critical role of mechanical forces in regulating the regenerative potential of stem cells. In collaboration with a drug discovery company, she also developed novel assays for screening drug candidates directly in vivo, leading to identification of a molecule to improve hematopoietic stem cell transplantation. As a graduate student, Karen had the opportunity to work with medical device projects through the Stanford Biodesign program, providing technical expertise. She is currently chief scientific officer at Cor Innovations, an early stage start-up developing an interventional device to prevent congestive heart failure.

Ryan received his Ph.D. in Mechanical Engineering, specializing on computational mechanics of biological tissues, from UC Berkeley in 2010. He received his M.S. and B.S. in Mechanical Engineering from Cal Poly, SLO in 2004 and 2003. During his graduate studies at Berkeley, he worked full-time at the Lawrence Livermore National Laboratories (LLNL) from 2005-2012, as lead hardware engineer on numerous large-scale hydrodynamic experiments. This work included mechanical fixture design, analysis and fabrication as well as project management (budget, scheduling and delegation of work). These projects introduced challenging materials (actinide metals) and design constraints including applications with high explosives, precision machining and extremely convoluted assemblies. Currently, Ryan is the Lead Mechanical Engineer at COR Innovations Inc. His work involves the design and fabrication of experimental equipment and device delivery prototypes. In addition to leading the design and implementation of COR's hardware needs, he provides computational expertise by implementing novel, three-dimensional finite element codes in efforts to both validate and augment the design of COR's passive heart restraint device.

Event Details
Event Details: 

Ryan and Karen will cover COR Innovations' solution to preventing congestive heart failure (CHF), following myocardial infarction (i.e. heart attack) with a minimally-invasive, device-based technology. Our presentation will include some background and statistics on CHF, previously proposed treatments as well as their shortcomings and finally our device. We will also cover our current testing and proposed future animal studies and experiments.